From APEX version 22.2 there's a changed behavior how active tabs or region display selectors (RDS) are stored in the browser session storage:
In versions before 22.2 they were stored without a prefix (session storage scope) and now they are stored with the prefix ORA_WWV_apex.apexTabs.
In some of my applications I've used a custom JS function to clear active tab:
From APEX 22.2 you need to set prefix:
Tested in APEX 22.2.0